Neurokinin A (Human, Porcine, Rat, Mouse)

Ref. 3D-PNK-4154

Product Information

• Name: Neurokinin A (Human, Porcine, Rat, Mouse)
• Synonyms: His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2 • 2AcOH • 5H2O Neuromedin L Substance K
• Brand: Biosynth
• Description: Neurokinin A is a peptide that is derived from the precursor protein, preprotachykinin A, and has been found to be an endogenous ligand for the NK-1 receptor. It is involved in a wide range of physiological processes such as neurotransmission and regulation of blood pressure. Neurokinin A has been shown to inhibit adenylate cyclase activity in guanethidine-sensitive tissues and ionophores-resistant cells. The effects of Neurokinin A are not due to its ability to bind to the NK-1 receptor but rather through other mechanisms. The amino acid sequence of this peptide was first determined by cloning methods in 1984 and it has since been used extensively as a tool for studying the function of this receptor. Neurokinin A also inhibits cell proliferation in glioma cells and has been shown to have an inhibitory effect on Ca2+ concentration during electrical nerve stimulation.

Chemical properties

• Molecular weight: 1,343.48 g/mol
• Formula: C₅₀H₈₀N₁₄O₁₄S•2CH₃COOH•5H₂O
• Purity: Min. 95%