H-GCK-OH

Ref. 3D-PP42858

Product Information

• Name: H-GCK-OH
• Synonyms: NH2-Gly-Cys-Lys-OH

Description

Peptide H-GCK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice. Recent citations using H-GCK-OH include the following: Integration of proteomics and metabolomics reveals energy and metabolic alterations induced by glucokinase (GCK) partial inactivation in hepatocytes Z Xie, J Liu, T Xie, P Liu, X Hui, Q Zhang , X Xiao - Cellular Signalling, 2024 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0898656823004242 increases in CEPT1 and ATGL elevate plasmalogen phosphatidylcholines in HDLs contributing to atheroprotective lipid profiles in hyperglycemic GCK X Wang, SM Lam , M Cao, T Wang, Z Wang, M Yu, B Li - Redox Biology, 2021 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S2213231721000033 GCK exonic mutations induce abnormal biochemical activities and result in GCK-MODY T Dai, Y Yang, J Zhang, X Ma, L Chen, C Zhang - Frontiers in , 2023 - frontiersin.orghttps://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2023.1120153 Structural basis for regulation of human glucokinase by glucokinase regulatory protein T Beck , BG Miller - Biochemistry, 2013 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/bi400838t Glucagon-like peptide 1 stimulates post-translational activation of glucokinase in pancreatic beta cells SY Ding, A Nkobena, CA Kraft, ML Markwardt - Journal of Biological , 2011 - ASBMBhttps://www.jbc.org/article/S0021-9258(20)51306-9/abstract Mechanistic origins of enzyme activation in human glucokinase variants associated with congenital hyperinsulinism SM Sternisha , P Liu, AG Marshall , BG Miller - Biochemistry, 2018 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acs.biochem.8b00022 Molecular and cellular regulation of human glucokinase SM Sternisha , BG Miller - Archives of biochemistry and biophysics, 2019 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0003986118310166 Nanosecond-timescale dynamics and conformational heterogeneity in human GCK regulation and disease SM Sternisha , AC Whittington , JAM Fiesco , C Porter - Biophysical journal, 2020 - cell.comhttps://www.cell.com/biophysj/pdf/S0006-3495(20)30006-0.pdf Mechanistic Enzymological Studies of Human Glucokinase and the Development of a Biocatalyst for Chemical Synthesis SM Sternisha - 2019 - search.proquest.comhttps://search.proquest.com/openview/26e97658eab9f4ea3a517ac645f4c154/1?pq-origsite=gscholar&cbl=18750&diss=y A novel pathogenic variant in the glucokinase gene found in two Japanese siblings with maturity-onset diabetes of the young 2 S Tanaka , H Akagawa, K Azuma, K Watanabe - Endocrine , 2023 - jstage.jst.go.jphttps://www.jstage.jst.go.jp/article/endocrj/70/6/70_EJ22-0541/_article/-char/ja/ The novel GCK variant p.Val455Leu associated with hyperinsulinism is susceptible to allosteric activation and is conducive to weight gain and the development of S Langer, R Waterstradt, G Hillebrand, R Santer - Diabetologia, 2021 - Springerhttps://link.springer.com/article/10.1007/s00125-021-05553-w Glucokinase, the pancreatic glucose sensor, is not the gut glucose sensor R Murphy , A Tura , PM Clark, JJ Holst , A Mari - Diabetologia, 2009 - Springerhttps://link.springer.com/article/10.1007/s00125-008-1183-9 Molecular physiology of mammalian glucokinase PB Iynedjian - Cellular and Molecular Life Sciences, 2009 - Springerhttps://link.springer.com/article/10.1007/s00018-008-8322-9 Tankyrase interacts with the allosteric site of glucokinase and inhibits its glucose-sensing function in the beta cell NW Chi, T Eisemann, TYJ Yeh, S Roy, TJ Chi, SH Lu - bioRxiv, 2021 - biorxiv.orghttps://www.biorxiv.org/content/10.1101/2021.08.08.454510.abstract Dairy product consumption interacts with glucokinase (GCK) gene polymorphisms associated with insulin resistance MS Da Silva, D Chartrand, MC Vohl, O Barbier - Journal of Personalized , 2017 - mdpi.comhttps://www.mdpi.com/2075-4426/7/3/8 Regulation of glucokinase by intracellular calcium levels in pancreatic beta cells ML Markwardt, KM Seckinger, MA Rizzo - Journal of Biological Chemistry, 2016 - ASBMBhttps://www.jbc.org/article/S0021-9258(20)34286-1/abstract Association with nitric oxide synthase on insulin secretory granules regulates glucokinase protein levels ML Markwardt, A Nkobena, SY Ding - Molecular , 2012 - academic.oup.comhttps://academic.oup.com/mend/article-abstract/26/9/1617/2614999 Motif analysis of phosphosites discloses a potential prominent role of the Golgi casein kinase (GCK) in the generation of human plasma phospho-proteome M Salvi , L Cesaro, E Tibaldi - Journal of proteome , 2010 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/pr100058r GCK-MODY diabetes as a protein misfolding disease: the mutation R275C promotes protein misfolding, self-association and cellular degradation M Negahdar, I Aukrust, J Molnes, MH Solheim - Molecular and Cellular , 2014 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0303720713003572 GCK-MODY diabetes associated with protein misfolding, cellular self-association and degradation M Negahdar, I Aukrust, BB Johansson , J Molnes - et Biophysica Acta (BBA , 2012 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0925443912001664 Insights into pathogenesis of five novel GCK mutations identified in Chinese MODY patients L Liu, Y Liu, X Ge, X Liu, C Chen, Y Wang , M Li , J Yin - Metabolism, 2018 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0026049518301938 Hormonal and metabolite regulation of hepatic glucokinase L Agius - Annual review of nutrition, 2016 - annualreviews.orghttps://www.annualreviews.org/doi/abs/10.1146/annurev-nutr-071715-051145 The fatty acid synthase fasn-1 acts upstream of WNK and Ste20/GCK-VI kinases to modulate antimicrobial peptide expression in C. elegans epidermis KZ Lee , M Kniazeva, M Han , N Pujol , J Ewbank - Virulence, 2010 - Taylor & Francishttps://www.tandfonline.com/doi/abs/10.4161/viru.1.3.10974 Nitric oxide activates beta-cell glucokinase by promoting formation of the"glucose-activated" state KM Seckinger, VP Rao, NE Snell, AE Mancini - Biochemistry, 2018 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acs.biochem.8b00333 Allosteric activation of human glucokinase JM Bowler - 2014 - search.proquest.comhttps://search.proquest.com/openview/c4cb6b5d922eec96fb26856dc4c30c25/1?pq-origsite=gscholar&cbl=18750 Antidiabetic Disruptors of the Glucokinase-Glucokinase Regulatory Protein Complex Reorganize a Coulombic Interface JA Martinez , Q Xiao, A Zakarian, BG Miller - Biochemistry, 2017 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acs.biochem.7b00377 Human pancreatic glucokinase. Structural and physico-chemical studies related to catalytic activation, kinetic cooperativity and GCK-diabetes. J Molnes - 2012 - bora.uib.nohttps://bora.uib.no/bora-xmlui/handle/1956/6235 Receptor-Mediated Regulation of Glucokinase by S-Nitrosylation in Hypothalamic Neurons J McFarland, MA Rizzo - Biophysical Journal, 2019 - cell.comhttps://www.cell.com/biophysj/pdf/S0006-3495(18)33651-8.pdf Post-Translational Regulation of Glucokinase in Hypothalamic Neurons J McFarland - 2020 - search.proquest.comhttps://search.proquest.com/openview/fd33d2ad951334bdec4454dddf736327/1?pq-origsite=gscholar&cbl=44156 L-Arginine prevents cereblon-mediated ubiquitination of glucokinase and stimulates glucose-6-phosphate production in pancreatic beta-cells J Cho , Y Horikawa, M Enya, J Takeda, Y Imai - Communications , 2020 - nature.comhttps://www.nature.com/articles/s42003-020-01226-3 Long term liver specific glucokinase gene defect induced diabetic cardiomyopathy by up regulating NADPH oxidase and down regulating insulin receptor and p H Li, X Wang, Y Mao, R Hu, W Xu, Z Lei, N Zhou - Cardiovascular , 2014 - Springerhttps://link.springer.com/article/10.1186/1475-2840-13-24 Virtual screening and prediction of binding of caprine CSN1S2 protein tryptic peptides to glucokinase F Fatchiyah , AH Rahasta, JRK Cairns - Acta Informatica Medica, 2017 - ncbi.nlm.nih.govhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723197/ Ingestion of a moderate high-sucrose diet results in glucose intolerance with reduced liver glucokinase activity and impaired glucagon-like peptide-1 secretion E Sakamoto, Y Seino, A Fukami - Journal of Diabetes , 2012 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1111/j.2040-1124.2012.00208.x The two major glucokinase isoforms show conserved functionality in beta-cells despite different subcellular distribution B Lu, M Munoz-Gomez, Y Ikeda - Biological Chemistry, 2018 - degruyter.comhttps://www.degruyter.com/document/doi/10.1515/hsz-2018-0109/html Impaired beta-cell glucokinase as an underlying mechanism in diet-induced diabetes B Lu, K Kurmi , M Munoz-Gomez - Disease models & , 2018 - journals.biologists.comhttps://journals.biologists.com/dmm/article-abstract/11/6/dmm033316/53316 Glucokinase (GCK) and other susceptibility genes for beta-cell dysfunction: the candidate approach AL Gloyn , ND Tribble, M Bunt , A Barrett, PRV Johnson - 2008 - portlandpress.comhttps://portlandpress.com/biochemsoctrans/article-abstract/36/3/306/66114 Kinetic basis of carbohydrate-mediated inhibition of human glucokinase by the glucokinase regulatory protein AK Casey, BG Miller - Biochemistry, 2016 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acs.biochem.6b00349 Dual allosteric activation mechanisms in monomeric human glucokinase AC Whittington , M Larion , JM Bowler - Proceedings of the , 2015 - National Acad Scienceshttps://www.pnas.org/doi/abs/10.1073/pnas.1506664112 Biochemical and biophysical investigations of the interaction between human glucokinase and pro-apoptotic BAD A Rexford, DAR Zorio , BG Miller - PLoS One, 2017 - journals.plos.orghttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0171587 Current Insight on the Role of Glucokinase and Glucokinase Regulatory Protein in Diabetes A Paliwal, V Paliwal, S Jain , S Paliwal - Mini Reviews in , 2024 - ingentaconnect.comhttps://www.ingentaconnect.com/content/ben/mrmc/2024/00000024/00000007/art00003

• Brand: Biosynth