HLA leader peptide LVL
Ref. 3D-PP45242
1mg
226.00€
10mg
263.00€
100mg
473.00€
Product Information
Name:HLA leader peptide LVL
Synonyms:
- H-VMAPRTLVL-OH NH2-Val-Met-Ala-Pro-Arg-Thr-Leu-Val-Leu-OH
Brand:Biosynth
Description:Fragment of the signal peptide from endogenous HLA Class I molecules which is also found in viral glycoproteins, for example human Cytomegalovirus (hCMV) protein UL40.
When presented on a cell surface via HLA-E molecules, the HLA- VMAPRTLVL complex binds NKG2A receptors on Natural Killer (NK) cells and some CD8⁺ cytotoxic T cells to reduce their cytotoxic activity. Blocking this interaction is an attractive opportunity for immune checkpoint (IC) approach therapies. This is relevant in both cancer therapies, and viral infections, where endogenous HLA Class I peptide presentation is exploited to escape immune attack.In one study, VMAPRTLVL UL4015-23 was found in 18% congenital cytomegalovirus (cCMV) strains.
When presented on a cell surface via HLA-E molecules, the HLA- VMAPRTLVL complex binds NKG2A receptors on Natural Killer (NK) cells and some CD8⁺ cytotoxic T cells to reduce their cytotoxic activity. Blocking this interaction is an attractive opportunity for immune checkpoint (IC) approach therapies. This is relevant in both cancer therapies, and viral infections, where endogenous HLA Class I peptide presentation is exploited to escape immune attack.In one study, VMAPRTLVL UL4015-23 was found in 18% congenital cytomegalovirus (cCMV) strains.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Technical inquiry about: HLA leader peptide LVL
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