H-IRK-OH

Ref. 3D-PP46450

Product Information

• Name: H-IRK-OH
• Synonyms: NH2-Ile-Arg-Lys-OH

Description

Peptide H-IRK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice. Recent citations using H-IRK-OH include the following: Simulation reveals two major docking pathways between the hexapeptide GDYMNM and the catalytic domain of the insulin receptor protein kinase Z Huang , CF Wong - Proteins: Structure, Function, and , 2012 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1002/prot.24116 Double trouble WT Miller - nature structural biology, 2001 - nature.comhttps://www.nature.com/articles/nsb0101_16 Cyclic Peptides Incorporating 4-Carboxyphenylalanine and Phosphotyrosine Are Potent Inhibitors of pp60c-src W Wang, L Ramdas, G Sun, S Ke, NU Obeyesekere - Biochemistry, 2000 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/bi992994f How do protein kinases discriminate between serine/threonine and tyrosine? Structural insights from the insulin receptor protein-tyrosine kinase SS Taylor, E Radzio-Andzelm, T Hunter - The FASEB Journal, 1995 - Wiley Online Libraryhttps://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.9.13.7557015 Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog SR Hubbard - The EMBO journal, 1997 - embopress.orghttps://www.embopress.org/doi/full/10.1093/emboj/16.18.5572 Assessing the range of kinase autoinhibition mechanisms in the insulin receptor family SC Artim, JM Mendrola, MA Lemmon - Biochemical Journal, 2012 - portlandpress.comhttps://portlandpress.com/biochemj/article-abstract/448/2/213/45787 serine/threonine and tyrosine? Structural insights from the insulin receptor protein-tyrosine kinase S SUSAN - FASEB J, 1994 - academia.eduhttps://www.academia.edu/download/66359608/1255.pdf Structural and biochemical evidence for an autoinhibitory role for tyrosine 984 in the juxtamembrane region of the insulin receptor S Li, ND Covino, EG Stein , JH Till - Journal of Biological , 2003 - ASBMBhttps://www.jbc.org/article/S0021-9258(19)75129-1/abstract Nanoparticle delivered human biliverdin reductase-based peptide increases glucose uptake by activating IRK/Akt/GSK3 axis: The peptide is effective in the cell and PEM Gibbs, T Miralem - Journal of Diabetes , 2016 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1155/2016/4712053 Human biliverdin reductase-based peptides activate and inhibit glucose uptake through direct interaction with the kinase domain of insulin receptor PEM Gibbs, N Lerner-Marmarosh, A Poulin - The FASEB , 2014 - ncbi.nlm.nih.govhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021440/ P-37: Role of the C-terminal domain of insulin receptor beta-subunit in aging: effects of truncation P Ruaca­z, C Martaca­nez, J Satracaºstegui - Experimental and , 1996 - thieme-connect.comhttps://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-0029-1211580.pdf Role of protein dynamics in allosteric control of the catalytic phosphoryl transfer of insulin receptor kinase P Ojeda-May, Y Li , V Ovchinnikov - Journal of the American , 2015 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/jacs.5b07996 Linear and Branched Forms of Short Antimicrobial Peptide-IRK Inhibit Growth of Multi Drug Resistant Staphylococcus aureus Isolates from Mastitic Cow Milk P Gogoi , S Shrivastava, P Shah, S Saxena - Journal of Peptide , 2021 - Springerhttps://link.springer.com/article/10.1007/s10989-021-10243-7 Modeling studies of the interactions between the insulin receptor kinase domain and protein tyrosine phosphatase 1B NR Glover, AS Tracey - Journal of the American Chemical Society, 1999 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/ja984354q Identification of a key element for hydrogen-bonding patterns between protein kinases and their inhibitors N Katayama, M Orita, T Yamaguchi - Proteins: Structure , 2008 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1002/prot.22207 Synthetic pentapeptides inhibiting autophosphorylation of insulin receptor in a non-ATP-competitive mechanism M Kato, M Abe, Y Kuroda, M Hirose - Journal of Peptide , 2009 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1002/psc.1114 Modelling of insulin receptor tyrosine kinase in its active form: a case study for validation of theoretical methods. K Ginalski, M Wojciechowski - Acta Biochimica , 1999 - ojs.ptbioch.edu.plhttps://ojs.ptbioch.edu.pl/index.php/abp/article/view/4132 ATP-dependent desensitization of insulin binding and tyrosine kinase activity of the insulin receptor kinase: the role of endosomal acidification JO Contreres, R Faure , G Baquiran, JJ Bergeron - Journal of Biological , 1998 - ASBMBhttps://www.jbc.org/article/S0021-9258(18)48877-1/abstract Engineering the substrate specificity of the Abl tyrosine kinase JH Till, PM Chan, WT Miller - Journal of Biological Chemistry, 1999 - ASBMBhttps://www.jbc.org/article/S0021-9258(19)87823-7/abstract Stabilization of ion selectivity filter by pore loop ion pairs in an inwardly rectifying potassium channel J Yang , M Yu, YN Jan , LY Jan - Proceedings of the , 1997 - National Acad Scienceshttps://www.pnas.org/doi/abs/10.1073/pnas.94.4.1568 Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2 J Wu, YD Tseng , CF Xu, TA Neubert - Nature structural & , 2008 - nature.comhttps://www.nature.com/articles/nsmb.1388 Peptide microarray analysis of the cross-talk between O-Glc NA cylation and tyrosine phosphorylation J Shi , T Tomašič , S Sharif, AJ Brouwer - FEBS , 2017 - Wiley Online Libraryhttps://febs.onlinelibrary.wiley.com/doi/abs/10.1002/1873-3468.12708 Human PTP1B-IRK III PTP1B-IRK - biology.kenyon.eduhttps://biology.kenyon.edu/BMB/Chime2/2006/PTP1b/ Steered molecular dynamics for investigating the interactions between insulin receptor tyrosine kinase (IRK) and variants of protein tyrosine phosphatase 1B (PTP1B) H Nguyen , N Do, T Phan, T Pham - Applied biochemistry and , 2018 - Springerhttps://link.springer.com/article/10.1007/s12010-017-2549-6 Inwardly rectifying K+ channels that may participate in K+ buffering are localized in microvilli of Schwann cells H Mi , TJ Deerinck, M Jones, MH Ellisman - Journal of , 1996 - Soc Neurosciencehttps://www.jneurosci.org/content/16/8/2421.short Molecular cloning and characterization of a gene coding for a putative receptor-like protein kinase with a Leucine-rich repeat expressed in inflorescence and root H Kanamoto, J Hattan, M Takemura , A YOKOTA - Plant , 2002 - jstage.jst.go.jphttps://www.jstage.jst.go.jp/article/plantbiotechnology/19/2/19_2_113/_article/-char/ja/ Inhibition of the insulin receptor kinase phosphorylation by nitric oxide: functional and structural aspects E Schmid, A Hotz-Wagenblatt - Antioxidants & Redox , 1999 - liebertpub.comhttps://www.liebertpub.com/doi/abs/10.1089/ars.1999.1.1-45 signaling events triggered by peroxovanadium [bpV (phen)] are insulin receptor kinase (IRK)-dependent: specificity of inhibition of IRK-associated protein tyrosine CJ Band, BI Posner , V Dumas - Molecular , 1997 - academic.oup.comhttps://academic.oup.com/mend/article-abstract/11/13/1899/2754068 Insulin Signaling: The Inside Story BIP OC, MD CQ - 2016 - researchgate.nethttps://www.researchgate.net/profile/Barry-Posner/publication/307939314_Insulin_Signalling_The_Inside_Story/links/5a8c6fd9aca27292c0f81dd2/Insulin-Signalling-The-Inside-Story.pdf The insulin receptor kinase: modulation and therapeutic implications BI Posner - Emerging Therapeutic Targets, 2000 - Taylor & Francishttps://www.tandfonline.com/doi/abs/10.1517/14728222.4.4.541 A computational study of the phosphorylation mechanism of the insulin receptor tyrosine kinase B Zhou, CF Wong - The Journal of Physical Chemistry A, 2009 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/jp810827w Bisubstrate analog probes for the insulin receptor protein tyrosine kinase: molecular yardsticks for analyzing catalytic mechanism and inhibitor design AC Hines, K Parang , RA Kohanski, SR Hubbard - Bioorganic , 2005 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0045206805000222 An investigation of protein kinase mechanism using bisubstrate analog inhibitors AC Hines - 2007 - search.proquest.comhttps://search.proquest.com/openview/25bb725ce16e06208814ea54e3c9bf81/1?pq-origsite=gscholar&cbl=18750 [28] Redox-mediated functional and structural changes in insulin receptor kinase A Hotz-Wagenblatt, W Dröge - Methods in enzymology, 2002 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0076687902486478 Unique substrate specificity of anaplastic lymphoma kinase (ALK): development of phosphoacceptor peptides for the assay of ALK activity A Donella-Deana, O Marin, L Cesaro, RH Gunby - Biochemistry, 2005 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/bi0472954

• Brand: Biosynth