H-LSARLAF-NH2
Ref. 3D-PP46836
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Product Information
- NH2-Leu-Ser-Ala-Arg-Leu-Ala-Phe-amide
Peptide H-LSARLAF-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice. Recent citations using H-LSARLAF-NH2 include the following: Inhibition of alphaIIbbeta3 Ligand Binding by an alphaIIb Peptide that Clasps the Hybrid Domain to the betaI Domain of beta3 WH Lee , E Schaffner-Reckinger , DC Tsoukatos - Plos one, 2015 - journals.plos.orghttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134952 The anti-platelet approach targeting the fibrinogen ligand of the GPIIb/IIIa receptor V Tsikaris - : An Official Publication of the European Peptide , 2004 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1002/psc.603 Association of CIB with GPIIb/IIIa during outside-in signaling is required for platelet spreading on fibrinogen UP Naik , MU Naik - Blood, 2003 - ashpublications.orghttps://ashpublications.org/blood/article-abstract/102/4/1355/17087 Complementary peptides that interfere with platelet aggregation and adherence TK Gartner, DB Taylor, J Derrick - Immunomethods, 1994 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S1058668784710497 Structure-activity relationships of alphaIIb 313-320 derived peptide inhibitors of human platelet aggregation RM Stanica, D Benaki , FI Rodis - European Peptide , 2008 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1002/psc.1060 A naturally occurring mutation near the amino terminus of alphaIIb defines a new region involved in ligand binding to alphaIIbbeta3 RB Basani, DL French, G Vilaire - Blood, The Journal , 2000 - ashpublications.orghttps://ashpublications.org/blood/article-abstract/95/1/180/180808 Extracellular disulfide exchange and the regulation of cellular function PA Jordan, JM Gibbins - Antioxidants & redox signaling, 2006 - liebertpub.comhttps://www.liebertpub.com/doi/abs/10.1089/ars.2006.8.312 A tripeptide mimetic of von Willebrand factor residues 981-983 enhances platelet adhesion to fibrinogen by signaling through integrin betaIIbbeta3 P Litjens, G Van Willigen, C Weeterings - Journal of Thrombosis , 2005 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S1538783622160551 Activation of glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic OM Alshehri , S Montague , S Watson - Biochemical , 2015 - portlandpress.comhttps://portlandpress.com/biochemj/article-abstract/468/3/459/48568 Thiols in the alphaIIbbeta3 integrin are necessary for platelet aggregation N Manickam , X Sun, KW Hakala - British journal of , 2008 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2141.2008.07200.x Vicinal thiols are required for activation of the alphaIIbbeta3 platelet integrin N Manickam , SS Ahmad , DW Essex - Journal of Thrombosis and , 2011 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S1538783622069677 Mapping the binding domains of the alphaIIb subunit: A study performed on the activated form of the platelet integrin alphaIIbbeta3 N Biris , M Abatzis, JV Mitsios - European journal of , 2003 - Wiley Online Libraryhttps://febs.onlinelibrary.wiley.com/doi/abs/10.1046/j.1432-1033.2003.03762.x alphaIIbbeta3-mediated outside-in signaling induced by the agonist peptide LSARLAF utilizes ADP and thromboxane A2 receptors to cause alpha-granule secretion by MJ Cho, J Liu , TI Pestina, SA Steward - Journal of Thrombosis , 2003 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S1538783622147045 Investigation of the role of adjacent amino acids to the 313-320 sequence of the alphaIIb subunit on platelet activation and fibrinogen binding to alphaIIbbeta3 JV Mitsios, G Stamos, FI Rodis, LD Tsironis - Platelets, 2006 - Taylor & Francishttps://www.tandfonline.com/doi/abs/10.1080/09537100500436713 Effect of synthetic peptides corresponding to residues 313-332 of the alphaIIb subunit on platelet activation and fibrinogen binding to alphaIIbbeta3 JV Mitsios, AP Tambaki, M Abatzis - European journal of , 2004 - Wiley Online Libraryhttps://febs.onlinelibrary.wiley.com/doi/abs/10.1111/j.1432-1033.2004.03990.x Distinct domains of alphaIIbbeta3 support different aspects of outside-in signal transduction and platelet activation induced by LSARLAF, an alphaIIbbeta3 interacting peptide JM Derrick, SJ Shattil, M Poncz - Thrombosis and , 2001 - thieme-connect.comhttps://www.thieme-connect.com/products/ejournals/html/10.1055/s-0037-1616147 Peptide LSARLAF activates alphaIIbbeta3 on resting platelets and causes resting platelet aggregate formation without platelet shape change JM Derrick, RG Loudon, TK Gartner - Thrombosis research, 1998 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0049384897002892 Characterization of a unique synthetic peptide which acts as a platelet agonist reveals evidence supporting novel integrin functions JM Derrick - 1997 - search.proquest.comhttps://search.proquest.com/openview/bc4ed565f06717fe132297c6890f3472/1?pq-origsite=gscholar&cbl=18750&diss=y The beta3 subunit of the integrin alphaIIbbeta3 regulates alphaIIb-mediated outside-in signaling J Liu , CW Jackson, RA Gruppo, LK Jennings - Blood, 2005 - ashpublications.orghttps://ashpublications.org/blood/article-abstract/105/11/4345/19508 Peptide LSARLAF induces integrin beta3 dependent outside-in signaling in platelets H Niu , Z Xu, D Li , L Zhang, K Wang, DB Taylor, J Liu - Thrombosis research, 2012 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0049384812001302 Protein disulfide isomerase and sulfhydryl-dependent pathways in platelet activation DW Essex , M Li, A Miller, RD Feinman - Biochemistry, 2001 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/bi002454e Redox modification of platelet glycoproteins DW Essex , M Li - Current drug targets, 2006 - ingentaconnect.comhttps://www.ingentaconnect.com/content/ben/cdt/2006/00000007/00000010/art00002 Redox control of platelet aggregation DW Essex , M Li - Biochemistry, 2003 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/bi0205045 Molecular basis of platelet activation by an alphaIIbbeta3-CHAMPS peptide B Grygielska, CE Hughes , SP Watson - Journal of Thrombosis and , 2009 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S153878362210632X The heptapeptide LSARLAF mediates platelet activation through phospholipase Cgamma2 independently of glycoprotein IIb-IIIa AC Pearce, P Wonerow, SJ Marshall - Biochemical , 2004 - portlandpress.comhttps://portlandpress.com/biochemj/article-abstract/378/1/193/41044
Chemical properties
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