Spy-Tag peptide

Ref. 3D-PP49636

Product Information

• Name: Spy-Tag peptide
• Synonyms: H-RGVPHIVMVDAYKRYK-OH
• Brand: Biosynth
• Description: SpyTag is a short peptide derived from the CnaB2 domain of the fibronectin-binding protein FbaB protein from Streptococcus pyogenes. The CnaB2 domain has a spontaneous isopeptide bond between Lys and Asp. By splitting and rational deisgn of this domain, the peptide (SpyTag) can be used in a pair to form an amide bond to its protein partner (SpyCatcher) in minutes. This ability to self-assemble through spontaneous isopeptide bond formation works across a wide range of aqueous buffer, pH and temperatures. Thsi system is therfore a valuable conjugation tool for biotechnolgy and bioengineering.Peptide tag forming a rapid covalent bond to a protein, through engineering a bacterial adhesinB. Zakeri, J.O. Fierer, E. Celik, E.C. Chittock, U. Schwarz-Linek, V.T. Moy, M. Howarth, Proc. Natl. Acad. Sci. U.S.A.109 (12) E690-E697 Catalyst-free thiazolidine formation chemistry enables the facile construction of peptide/protein-cell conjugates (PCCs) at physiological pH X Liu, Y Wang, B Ye, X Bi - Chemical Science, 2023 - pubs.rsc.orghttps://pubs.rsc.org/en/content/articlehtml/2023/sc/d3sc01382k AlbuCatcher for Long-Acting Therapeutics JH Rho, JH Lee, I Kwon - ACS omega, 2024 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acsomega.4c02303 T Cell Activating Thermostable Self-Assembly Nanoscaffold Tailored for Cellular Immunity Antigen Delivery J Zhang, J Yang, Q Li, R Peng, S Fan, H Yi - Advanced , 2023 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1002/advs.202303049

Chemical properties

• Color/Form: Powder