BH3 BIM (52 - 71)

Ref. 3D-PP50284

Product Information

• Name: BH3 BIM (52 - 71)
• Synonyms: Bim BH3(52-71)amideAc-MRPEIWIAQELRRIGDEFNA-NH2Ac-Met-Arg-Pro-Glu-Ile-Trp-Ile-Ala-Gln-Glu-Leu-Arg-Arg-Ile-Gly-Asp-Glu-Phe-Asn-Ala-a mide
• Brand: Biosynth
• Description: The BH3 BIM (52-71), human peptide is a synthetic peptide derived from the BIM protein (Bcl-2-like protein 11), which is a member of the BH3-only family of pro-apoptotic proteins. This specific peptide corresponds to amino acids 52 to 71 of the human BIM protein, and it contains the BH3 domain—a critical region responsible for its interaction with anti-apoptotic members of the Bcl-2 family, such as Bcl-2, Bcl-xL, and Mcl-1.The BH3 domain is essential for the pro-apoptotic function of BIM. It binds to anti-apoptotic proteins, neutralizing their activity and allowing pro-apoptotic proteins like Bax and Bak to promote mitochondrial outer membrane permeabilization (MOMP), which leads to apoptosis (programmed cell death). This mechanism is crucial in regulating cell death, especially in cancer and other diseases where apoptosis is dysregulated.

Chemical properties

• Molecular weight: 2,485.9 g/mol
• Formula: C₁₁₀H₁₇₃O₃₁N₃₃S₁