Puma2A peptide

Ref. 3D-PP50468

Product Information

• Name: Puma2A peptide
• Synonyms: Ac-EQWAREIGAQARRMAADLNA-NH2
• Brand: Biosynth
• Description: PUMA2A is a modified version of the PUMA peptide, a pro-apoptotic protein that promotes cell death. PUMA normally activates proteins like BAK and BAX, which cause mitochondrial damage and trigger apoptosis. However, PUMA2A has two alanine substitutions that render it inactive. It's often used as a negative control in experiments studying apoptosis, as it should not induce cell death. This is because the BCL-2 family of proteins, which includes PUMA, are crucial regulators of apoptosis, and disrupting their function can impact cell survival.