[D-Arg1,D-Trp7,9,Leu11]-Substance P

Ref. 3D-PSP-4173

Product Information

• Name: [D-Arg1,D-Trp7,9,Leu11]-Substance P
• Synonyms: D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2 • 3HCl • 8H2OSpantide
• Brand: Biosynth
• Description: This product is a Substance P antagonist. Substance P is a neuropeptide that acts as a neurotransmitter and neuromodulator. It is best known for its role in nociception or pain perception. Substance P is also involved in other biological processes such as the regulation of gastrointestinal motility and the inflammatory response. As a tachykinin neuropeptide, substance P acts through binding to its specific neurokinin 1 receptor (NK-1R). NK-1R is present in neurons and on glial cell types. Substance P is also involved in: increased inflammation in the lungs, gastrointestinal tract and the skin and neuroinflammation. Interestingly the levels of Substance P are raised in inflammatory bowel diseases and through its involvement in cytokine release, it contributes to asthma pathology. These diverse selection of functions makes substance P a target for therapeutic research.

Chemical properties

• Molecular weight: 1,751.3 g/mol
• Formula: C₇₅H₁₀₈N₂₀O₁₃•3HCI•8H₂O
• Purity: Min. 95%