Product Information
AS 2521780 is a potent and selective inhibitor of the enzyme tyrosine phosphatase-1B (PTP-1B) that is used to treat autoimmune diseases. PTP-1B inhibitors are used as immunosuppressants in patients undergoing renal transplantation or other types of organ transplants, or for the treatment of cardiac diseases. AS 2521780 has been shown to inhibit the proliferation of T cells and CD4+CD25+Foxp3+ regulatory T cells. This drug also inhibits the proliferation of mononuclear cells, which are found in blood, and reduces the production of cytokines by these cells. The inhibition of PTP-1B may be involved in many aspects of cell function, including insulin secretion from pancreatic beta cells, glucose metabolism in muscle cells, and cardiac contractility. AS 2521780 is a potential drug target for diabetes mellitus type 2 and heart failure.
Chemical properties
Technical inquiry about: 3D-PYB72689 AS 2521780
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