Avermectin a1a

CAS: 65195-51-9

Ref. 3D-QCA19551

Product Information

• Name: Avermectin a1a
• Synonyms: Spiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2′-[2H]pyran]-17-one, 7-[[2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-3-O-methyl-α-L-arabino-hexopyranosyl]oxy]-5′,6,6′,7,10,11,14,15,17a,20,20a,20b-dodecahydro-20b-hydroxy-20-methoxy-5′,6,8,19-tetramethyl-6′-(1-methylpropyl)-, [6S-[2aE,4E,6R*,7R*,8E,11S*,13R*[5′R*,6′S*(R*)],15R*,17aS*,20S*,20aS*,20bR*]]-, Antibiotic C 076A1a, [6S-[2aE,4E,6R*,7R*,8E,11S*,13R*[5′R*,6′S*(R*)],15R*,17aS*,20S*,20aS*,20bR*]]-7-[[2,6-Dideoxy-4-O-(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-3-O-methyl-α-L-arabino-hexopyranosyl]oxy]-5′,6,6′,7,10,11,14,15,17a,20,20a,20b-dodecahydro-20b-hydroxy-20-methoxy-5′,6,8,19-tetramethyl-6′-(1-methylpropyl)spiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2′-[2H]pyran]-17-one, Spiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2′-[2H]pyran], avermectin A1a deriv., Avermectin A1a

Description

Avermectin a1a is an analog of the antiparasitic drug ivermectin, which has been shown to have anticancer properties. It induces apoptosis in cancer cells and has been tested on various types of tumors, including those found in the urine and Chinese hamster ovary cells. Avermectin a1a has also been shown to inhibit kinase activity, particularly protein kinases such as CDK2 and GSK-3β. This inhibition leads to decreased cell proliferation and increased cell death, making it a promising candidate for cancer treatment. Additionally, Avermectin a1a has been found to be effective against indirubin-resistant human cancer cell lines, suggesting that it may have potential as an inhibitor of drug resistance in cancer therapy.

• Brand: Biosynth

Chemical properties

• Molecular weight: 887.1 g/mol
• Formula: C₄₉H₇₄O₁₄
• Purity: 90%