3-o-Acetyl ezetimibe-d4 2,3,4-tri-o-acetyl-β-D-glucuronide methyl ester

CAS: 190448-56-7

Ref. 3D-QHA44856

Product Information

• Name: 3-o-Acetyl ezetimibe-d4 2,3,4-tri-o-acetyl-β-D-glucuronide methyl ester
• Brand: Biosynth
• Description: Ezetimibe is a potent inhibitor of cholesterol absorption. It inhibits the intestinal absorption of cholesterol by binding to the NPC1L1 protein, which is expressed in the brush border membrane of enterocytes. Ezetimibe competes with dietary cholesterol for the NPC1L1 protein, thereby preventing the transport of cholesterol across the intestinal wall and into the body. This drug has been shown to decrease total and low-density lipoprotein (LDL) cholesterol levels, as well as Apolipoprotein B levels in humans. The mechanism of action for ezetimibe is not fully understood but is thought to be due in part to its ability to inhibit sterol regulatory element-binding proteins (SREBPs). Ezetimibe has also been shown to activate peroxisome proliferator-activated receptor-gamma (PPARγ), increase high-density lipoprotein (HDL) levels, and inhibit platelet aggregation.

Chemical properties

• Molecular weight: 767.7 g/mol
• Formula: C₃₉H₃₉F₂NO₁₃
• Purity: Min. 95%