Methylenebis-phosphonic acid tetramethyl ester

CAS: 16001-93-7

Ref. 3D-RAA00193

Product Information

• Name: Methylenebis-phosphonic acid tetramethyl ester
• Brand: Biosynth
• Description: Methylenebisphosphonic acid is a phosphonic acid with an inhibitory effect on enzymes. It has been shown to have strong inhibitory properties against gram-negative bacteria and inhibits the growth of Mycobacterium tuberculosis. Methylenebisphosphonic acid also inhibits the production of cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), by inflammatory cells, which may contribute to its anti-inflammatory properties. Methylenebisphosphonic acid also blocks apoptotic cell death by inhibiting the activation of caspase 3, an enzyme that cleaves other proteins involved in apoptosis. Methylenebisphosphonic acid binds to Ca2+ response proteins and blocks their ability to regulate cellular processes. This prevents the release of cytochrome C from mitochondria, which initiates a cascade of reactions leading to cell death.

Chemical properties

• Molecular weight: 232.11 g/mol
• Formula: C₅H₁₄O₆P₂
• Purity: Min. 95%