Product Information
- 4(1H)-Quinazolinone, 6-hydroxy-
- 4(3H)-Quinazolinone, 6-hydroxy-
- 4,6-Dihydroxyquinazoline
- 6-Hydroxy-3,4-Dihydroquinazolone
- 6-Hydroxy-3,4-dihydroquinazolin-4-one
- 6-Hydroxy-3H-quinazolin-4-one
- 6-Hydroxy-4(3H)-quinazolinone
- 6-Hydroxy-4-Quinazolinone
- 6-Hydroxy-4-quinazolone
- 6-Hydroxyquinazolin-4(3H)-One
- See more synonyms
- 6-Hydroxyquinazolin-4-Ol
- 6-hydroxyquinazolin-4(1H)-one
- Quinazoline-4,6-diol
6-Hydroxyquinazolin-4(1H)-one is a potent inhibitor of the tyrosine kinase, which blocks the growth of cancer cells and tumor progression. It has been shown to inhibit the growth of human esophageal cancer cells in vitro and in vivo. 6-Hydroxyquinazolin-4(1H)-one inhibits the activity of EGFR tyrosine kinase in these cells. This drug also inhibits the cell proliferation induced by lapatinib, a drug that blocks the activity of HER2 protein tyrosine kinase. 6-Hydroxyquinazolin-4(1H)-one is an inhibitor that belongs to the class of dithiocarbamic compounds. It competitively binds to metal ions such as zinc or copper, which are necessary for enzyme activity. In addition, it inhibits cancer cell growth by inhibition of protein synthesis through interference with ribosomes and RNA polymerases.
Chemical properties
Technical inquiry about: 3D-RAA06410 6-Hydroxyquinazolin-4(1H)-one
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