Product Information
- 2-Hydroxy-5-tert-butylbenzoic acid
- 5-(1,1-Dimethylethyl)-2-hydroxybenzoic acid
- 5-Tert-Butyl-2-Hydroxybenzoic Acid
- 5-tert-Butylsalicylic acid
- Ai3-25423
- Benzoic acid, 5-(1,1-dimethylethyl)-2-hydroxy-
- NSC 53153
- NSC 94402
- Salicylic acid, 5-tert-butyl-
5-tert-Butyl-2-hydroxybenzoic acid (5BHB) is a synthetic, hydrophobic and polyvalent compound that can reversibly activate xenobiotic metabolizing enzymes. 5BHB has been shown to induce CYP1A2 activity in human liver cells, as well as increase the activity of other xenobiotic metabolizing enzymes such as CYP3A4, CYP2D6, and CYP2C19. This activation occurs through the direct binding of 5BHB to nuclear receptors, which are proteins embedded within the cell membrane that bind with specific hormones or other molecules. A cavity within the receptor binds with the hydrophobic 5BHB molecule. The activation of these enzymes leads to increased metabolism of foreign compounds in the body and may be beneficial in reducing drug toxicity.
Chemical properties
Technical inquiry about: 3D-RAA09431 5-tert-Butyl-2-hydroxybenzoic acid
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