4-{[(Diaminomethylidene)amino]methyl}benzoic acid

CAS: 41651-87-0

Ref. 3D-RBA65187

Product Information

• Name: 4-{[(Diaminomethylidene)amino]methyl}benzoic acid
• Brand: Biosynth
• Description: 4-(Diaminomethylidene)amino-N-methylbenzoic acid (DABA) is a potent histone deacetylase inhibitor that has been shown to inhibit the growth of cancer cells in vitro. DABA binds to the hydrophobic pocket of the acetyltransferase domain of the HDAC enzyme and prevents its interaction with the substrate lysine, inhibiting histone acetylation. In addition, DABA also inhibits platelet aggregation by reducing ATP production in platelets, which may be due to its ability to inhibit protein kinase A activity. The molecular modeling study demonstrated that DABA fits well into the hydrophobic pocket of HDAC2, with potential for binding to other HDACs.

Chemical properties

• Molecular weight: 193.2 g/mol
• Formula: C₉H₁₁N₃O₂
• Purity: Min. 95%