N-Hydroxy-3-[1-(phenylthio)methyl-1H-1,2,3-triazol-4-yl]benzamide

CAS: 1316652-41-1

Ref. 3D-RCC65241

Product Information

• Name: N-Hydroxy-3-[1-(phenylthio)methyl-1H-1,2,3-triazol-4-yl]benzamide
• Brand: Biosynth
• Description: N-Hydroxy-3-[1-(phenylthio)methyl-1H-1,2,3-triazol-4-yl]benzamide (NHTB) is a histone deacetylase inhibitor that binds to the active site of the enzyme and inhibits its activity. It is selective for class I HDACs over class II HDACs. NHTB has been shown to inhibit acetylation of α-tubulin in vitro and in vivo. The compound also inhibits proliferation of T cells from patients with cutaneous T cell lymphoma and promotes apoptosis. NHTB also has antiangiogenic effects by inhibiting proliferation of endothelial cells.

Chemical properties

• Molecular weight: 326.37 g/mol
• Formula: C₁₆H₁₄N₄O₂S
• Purity: Min. 95%