Product Information
BM 957 is a potent and selective protein inhibitor that binds to the ATP-binding site of the enzyme, FKBP12. It inhibits the activity of FKBP12 in the cell and mitochondria by preventing it from binding to its natural substrate, FK506. BM 957 has been shown to inhibit the growth of cancer cells and induce apoptosis. This drug also inhibits cell proliferation by inhibiting protein synthesis. The high values observed in pharmacokinetic studies may be due to its ability to cross the blood-brain barrier. BM 957 is highly potent against chemoresistant tumor cells, which is likely due to its ability to inhibit cell growth, inducing apoptotic cell death.
Chemical properties
Technical inquiry about: 3D-RFC10754 BM 957
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