8-Aminoquinoline-3-carboxylic acid

CAS: 1416439-58-1

Ref. 3D-RGC43958

Product Information

• Name: 8-Aminoquinoline-3-carboxylic acid
• Brand: Biosynth
• Description: 8-Aminoquinoline-3-carboxylic acid is a small molecule that inhibits the activity of the enzyme, catechol-O-methyltransferase (COMT), which is responsible for the demethylation of dopamine. 8-Aminoquinoline-3-carboxylic acid has been shown to be potent and selective in inhibiting COMT and thereby preventing the degradation of dopamine. This compound has been used in screening assays to identify other small molecules that can act as COMT inhibitors. The role of COMT in neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease has been investigated using this inhibitor as a model system. 8-Aminoquinoline-3-carboxylic acid also binds to methylated DNA, which may explain its effect on cellular growth factor signaling pathways.

Chemical properties

• Molecular weight: 188.19 g/mol
• Formula: C₁₀H₈N₂O₂
• Purity: Min. 95%
• Color/Form: Powder