Product Information
AS2863619 is a small-molecule drug that activates the phosphoinositide 3-kinase (PI3K) and mitogen activated protein kinase (MAPK) signaling pathways. It has been shown to have a functional effect on inflammatory cytokines, cell function, and hypomethylation of DNA. AS2863619 has also been shown to be able to activate the TGF-β pathway in vitro and in vivo. This compound is selective for certain regulatory kinases, such as PI3K and MAPK, but not others. AS2863619 is also an inhibitor of DNA methyltransferase 1 (DNMT1). As such, it is able to inhibit the expression of genes by preventing methylation of their promoter regions. The activation of these pathways leads to increased proliferation activity.
Chemical properties
Technical inquiry about: 3D-RPD30050 AS2863619
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