Product Information
AT-527 is a natural product that has been shown to have antiparasitic, antibiotic, and antibacterial activities. It is derived from Streptomyces sp. AT-527 produces an active metabolite that inhibits the growth of bacteria by binding to the 50S ribosomal subunit. This binding prevents the formation of an antibiotic-inhibitor complex with the enzyme cell wall synthesis that is required for cell wall biosynthesis, inhibiting protein synthesis and cell division. AT-527 also inhibits viral replication by inhibiting RNA polymerase activity and DNA transcription, which leads to inhibition of protein expression and virus assembly.
AT-527 was found to be active against a variety of microorganisms including fungi and parasites as well as influenza A (H1N1) virus in vitro.
Chemical properties
Technical inquiry about: 3D-RPD33784 AT-527
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