Product Information
EGFR-IN-7 is a mutant of epidermal growth factor receptor (EGFR) that has been shown to be resistant to EGFR tyrosine kinase inhibitors. EGFR-IN-7 has been shown to bind to ubiquitin and inhibit ubiquitin ligases, which are enzymes that regulate the degradation of proteins. This inhibition leads to increased levels of the EGFR protein, resulting in an increase in the frequency of cells with an activated EGFR receptor. The accumulation of these cells may lead to tumor formation if left unchecked. It has also been shown that this mutant binds to other receptors on the cell surface, such as Factor Receptor, thereby increasing its potential for cellular transformation. EGFR-IN-7 has proven effective at inhibiting proliferation in cancer cells.
Chemical properties
Technical inquiry about: 3D-SQD32976 EGFR-IN-7
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