Product Information
Name:Poly(2'-Fluoro-2'-Deoxyadenylic Acid)
Brand:Biosynth
Description:Poly(2'-Fluoro-2'-Deoxyadenylic Acid) (PFDAA) is a synthetic analog of natural RNA polymerase II α subunit. It has been shown to be a potent inhibitor of protein synthesis in vitro, with an IC50 of 1 μM. PFDAA has been used as a primer in PCR reactions and as a template for transcription reactions. In these reactions, PFDAA was able to phosphorylate the β-subunit of RNA polymerase II and to induce transcriptase activity, but not DNA replication. The divalent cation requirement for this reaction may be due to the formation of a ternary complex with the template strand and ATP.
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Chemical properties
Molecular weight:443.18 g/mol
Formula:C10H12FN5O10P2
Purity:Min. 95%
Technical inquiry about: Poly(2'-Fluoro-2'-Deoxyadenylic Acid)
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