Product Information
PYR 41 is a small molecule that inhibits the activity of the ATP-binding cassette (ABC) transporter P-glycoprotein. This protein is responsible for the efflux of many drug molecules, including chemotherapeutic agents, from cells. PYR 41 can be used to inhibit this efflux in order to increase the concentration of drugs in cancer cells. The effect of PYR 41 was tested on a mouse model of skin injury and has been shown to reduce the extent of inflammation and epidermal growth factor levels. In addition, it has been shown to have anti-inflammatory effects in experimental models of autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. The mechanism by which PYR 41 works is not yet clear but may involve inhibition of some enzyme activities or inhibition of response elements.
Chemical properties
Technical inquiry about: 3D-TRA80502 PYR 41
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