Product Information
- 3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxybenzamide
- 3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridyl)-p-anisamide
- 3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamide
- Benzamide, 3-(cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxy-
- Ccris 8304
- Cpodpmb
- N-(3,5-Dichloropyrid-4-yl)-3-cyclopentyloxy-4-methoxybenzamide
- Piclamilast [INN]
- Rp 73401
- Rpr 73401
- See more synonyms
Piclamilast is a low-potency, non-selective, reversible inhibitor of phosphodiesterase (PDE) enzymes. It has been shown to have therapeutic potential for inflammatory bowel disease and asthma. Piclamilast blocks the production of pro-inflammatory cytokines such as eosinophil cationic protein and basic proteins in response to lipopolysaccharide (LPS).
Piclamilast inhibits the inflammatory response induced by LPS by reducing the expression of pro-inflammatory cytokines, including IL-8, IL-1β, TNFα and IL-6.
Piclamilast also has inhibitory effects on protein kinases such as c-jun phosphorylation and polymerase chain reaction.
Chemical properties
Technical inquiry about: 3D-UFA03583 Piclamilast
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