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Isofagomine
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Isofagomine

CAS: 169105-89-9

Ref. 3D-UGA10589

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Estimated delivery in United States, on Monday 13 Jan 2025

Product Information

Name:
Isofagomine
Synonyms:
  • (3R,4R,5R)-5-(Hydroxymethyl)-3,4-Piperidinediol, Hydrochloride
  • (3R,4R,5R)-5-(Hydroxymethyl)-3,4-piperidinediol
  • (3R,4R,5R)-5-(Hydroxymethyl)-3,4-piperidinediol,HCl
  • (3R,4R,5S)-5-(hydroxymethyl)piperidine-3,4-diol
  • 3,4-Piperidinediol, 5-(hydroxymethyl)-, (3R,4R,5R)-
  • 3,4-Piperidinediol, 5-(hydroxymethyl)-, [3R-(3α,4β,5α)]-
  • <span class="text-smallcaps">D</span>-Isofagomine
  • Afegostat
  • IsofagomineHydrochlroide
  • Plicera
  • See more synonyms
Description:

Isofagomine is a chiral molecule that has been used as a model system for studying the stereochemical effects of enzyme inhibition. It is an inhibitor of the enzyme glucosylceramide synthase, which is involved in the synthesis of glucosylceramide (a major component of the myelin sheath). Isofagomine binds to an allosteric site on this enzyme and inhibits its activity. The binding site on glucosylceramide synthase has been mapped using X-ray crystallography and NMR spectroscopy. Isofagomine also inhibits other enzymes, such as phosphatidylethanolamine N-methyltransferase, which catalyzes the transfer of methyl groups from S-adenosylmethionine to phosphatidylethanolamine. Isofagomine has been shown to have neuroprotective properties against oxidative injury by reducing lipid peroxidation in rat brain cells. This may

Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
Biosynth
Long term storage:
Notes:

Chemical properties

Molecular weight:
147.17 g/mol
Formula:
C6H13NO3
Purity:
Min. 95%
MDL:
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EINECS:
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HS code:

Hazard Info

UN Number:
EQ:
Class:
H Statements:
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Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

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