Product Information
Autophinib is a mitochondria-targeted drug that inhibits the mitochondrial membrane potential. It has been shown to suppress tumor growth in human osteosarcoma cells and in carcinoma cell lines by inducing apoptosis, which is mediated by a pathway involving 17β-estradiol, toll-like receptor (TLR) signaling, and autophagy. Autophinib also induces epithelial mesenchymal transition and inhibits autophagy in 17β-estradiol resistant cells. Autophinib is designed to target mitochondria of cancer cells, which are dependent on increased energy metabolism for tumor growth. This drug inhibits the production of reactive oxygen species (ROS) from mitochondria and thus prevents oxidative stress.
Chemical properties
Technical inquiry about: 3D-UQC44347 Autophinib
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