BMF peptide

Ref. 3D-VAC-00946

Product Information

• Name: BMF peptide
• Synonyms: Ac-WHQAEVQIARKLQLIADQFHR-NH2 TFA salt
• Brand: Biosynth
• Description: The Bmf peptide is a short fragment derived from the protein Bmf (Bcl-2-modifying factor), which is a pro-apoptotic member of the BH3-only family of proteins. These proteins play crucial roles in regulating apoptosis by interacting with other members of the Bcl-2 family, such as Bax and Bak, to promote cell death.The Bmf peptide specifically refers to a portion of the Bmf protein that contains the BH3 domain—a critical region responsible for its interaction with anti-apoptotic Bcl-2 proteins. This interaction inhibits the survival-promoting activity of Bcl-2 proteins, thereby triggering apoptosis.In research and therapeutic contexts, peptides like Bmf are used to mimic the action of natural BH3-only proteins to help in BH3 profiling; Bmf promotes apoptosis in cancer cells or other diseased tissues by targeting the apoptotic pathways regulated by Bcl-2 family proteins. By doing so, they help in restoring the natural cell death process in cells that are evading apoptosis, such as in cancer.