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GSK-239512
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GSK-239512

CAS: 720691-69-0

Ref. 3D-VDB69169

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Estimated delivery in United States, on Tuesday 21 Jan 2025

Product Information

Name:
GSK-239512
Description:

GSK-239512 is a clinical candidate for the treatment of chronic inflammatory diseases. It is a potent antagonist of the IL-6 receptor and has been shown to have immunomodulatory effects in preclinical models. GSK-239512 has been studied in an oral chronic toxicity study in rats at doses of up to 600 mg/kg/day for 18 months, with no evidence of any toxic effect. The drug was not found to cross the blood-brain barrier or cause any effect on the central nervous system. In molecular modeling studies, GSK-239512 was found to bind to IL-6 receptors and block signaling pathways associated with inflammation, including those that lead to neutrophil recruitment, endothelial activation and platelet aggregation.
GSK-239512 has been shown to be safe at doses up to 600 mg/kg/day in nonclinical studies and was well tolerated by animals at doses up to 600 mg/kg/day in a long term

Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
Biosynth
Long term storage:
Notes:

Chemical properties

Molecular weight:
377.48 g/mol
Formula:
C23H27N3O2
Purity:
Min. 95%
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Hazard Info

UN Number:
EQ:
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H Statements:
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Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

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