2,3-Dihydro-2-[[4-methoxy-3-[2-(3-methylphenyl)ethoxy]benzoyl]amino]-1H-Indene-2-carboxylic Acid

CAS: 1195941-38-8

Ref. 3D-VXB94138

Product Information

• Name: 2,3-Dihydro-2-[[4-methoxy-3-[2-(3-methylphenyl)ethoxy]benzoyl]amino]-1H-Indene-2-carboxylic Acid
• Brand: Biosynth
• Description: 2,3-Dihydro-2-[[4-methoxy-3-[2-(3-methylphenyl)ethoxy]benzoyl]amino]-1H-Indene-2-carboxylic Acid (MK0893) is a small molecule that belongs to the class of indole carboxamides. It is a potent and selective inhibitor of phosphodiesterase 1 (PDE1), with an IC50 value of less than 10 nM. MK0893 inhibits PDE1 in vitro and in vivo, leading to increased cAMP levels, vasodilation, and induction of nitric oxide synthase. MK0893 has been shown to have therapeutic efficacy in animal models of systemic sclerosis. In these models, MK0893 inhibited the development of skin fibrosis by inhibiting TGFβ signaling, which is implicated in the pathogenesis of systemic sclerosis.

Chemical properties

• Molecular weight: 445.51 g/mol
• Formula: C₂₇H₂₇NO₅
• Purity: Min. 95%