5-Androstenediol

CAS: 521-17-5

Ref. 3D-W-105849

Product Information

• Name: 5-Androstenediol
• Synonyms: Hermaphrodiol (3S,8R,9S,10R,13S,14S,17S)-10,13-Dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanth rene-3,17-diol, (3S,8R,9S,10R,13S, 14S,17S)-10,13-Dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,17-diol, (3β,17β)-Androst-5-ene-3,17-diol, 3β,17β-Androst-5-enediol, 3β,17β-Dihydroxyandrost-5-ene, 5-Androstene-3β,17β-diol, Androst-5-Ene-3-Β,17-Β-Diol, Androst-5-Eno-3-Β,17-Β-Diol, Androst-5-en-3-β,17-β-diol, Androst-5-ene-3β,17β-diol, Androst-5-enediol, Androstenediol, HE 2100 (estrogen receptor agonist), He 2100, Hermaphrodiol, Neumune, Nsc 12163, Δ5-Androstene-3β,17β-diol, Δ5-Androstenediol, Δ⁵-Androstene-3β,17β-diol, Δ⁵-Androstenediol

Description

5-Androstenediol is a metabolite of the steroid hormone testosterone. It has been shown to induce cellular transformation in vitro and to inhibit the growth of cancer cells, such as prostate cancer cells, by interfering with DNA replication. 5-Androstenediol binds to receptor sites in the nucleus, which inhibits both protein synthesis and cell division. This compound also induces pluripotent cells from mouse embryonic fibroblasts and has been shown to be an effective chemotherapeutic agent against leukemia, lymphoma, and breast cancer. The binding of 5-androstenediol to DNA is dependent on the dinucleotide phosphate (dNTP) concentration. The dNTP concentration can be determined by an analytical method called hydrolysis-fluorimetric phosphoimaging assay (HFIA).
5-Androstenediol can also inhibit Toll-like receptor 4 (TLR4) signaling in macrophages, leading to decreased production of proinflammatory cytokines.

• Brand: Biosynth

Chemical properties

• Molecular weight: 290.44 g/mol
• Formula: C₁₉H₃₀O₂
• Purity: Min. 98.0 Area-%