Product Information
Name:2,5-dimethyl-4-nitropyridin-1-ium-1-olate
Brand:Biosynth
Description:2,5-Dimethyl-4-nitropyridin-1-ium-1-olate (DMNPE) is a ligand that binds to the estrogen receptor. DMNPE has been shown to be an effective chemotherapeutic agent for cancer cells in the mononuclear cell line Mcf7. DMNPE also inhibits tumor growth and metastasis in a murine leukemia model. It has been shown to bind to the nongenomic binding site of the estrogen receptor and act as an antagonist of estradiol by competing with estradiol for binding sites on the estrogen receptor. DMNPE is able to bind to two different receptors, which may account for its observed anti-tumor effects. It has been shown to inhibit protein synthesis by methylating proteins and inhibiting DNA synthesis through inhibition of ribonucleotide reductase activity.
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Chemical properties
Molecular weight:168.15 g/mol
Formula:C7H8N2O3
Purity:Min. 95%
Technical inquiry about: 2,5-dimethyl-4-nitropyridin-1-ium-1-olate
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