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5-Bromo-6-nitro-1H-indazole
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5-Bromo-6-nitro-1H-indazole

CAS: 71785-49-4

Ref. 3D-WCA78549

250mg
229.00 €
2500mg
894.00 €
Estimated delivery in United States, on Tuesday 7 Jan 2025

Product Information

Name:
5-Bromo-6-nitro-1H-indazole
Synonyms:
  • 1H-Indazole, 5-bromo-6-nitro-
Description:

5-Bromo-6-nitro-1H-indazole is a potent inhibitor of ATP binding to the ATP binding site on kinases. It has shown antiproliferative activities in prostate cancer cells, PC3 cells and in vivo models. 5-Bromo-6-nitro-1H-indazole has been shown to inhibit the activity of protein kinases with micromolar potency. The IC50 values obtained from experiments are in the micromolar range for different kinases, including casein kinase II (CKII), cAMP dependent protein kinase A (PKA), and mitogen activated protein kinase 1 (MAPK1). The inhibition of these three kinases was found to be competitive and reversible. 5BINI also inhibits phosphorylation of casein by CKII, which is an important mechanism for regulating the activity of this enzyme.

Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
Biosynth
Long term storage:
Notes:

Chemical properties

Molecular weight:
242.03 g/mol
Formula:
C7H4BrN3O2
Purity:
Min. 95%
MDL:
Melting point:
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Concentration:
EINECS:
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HS code:

Hazard Info

UN Number:
EQ:
Class:
H Statements:
P Statements:
Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

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