Heliosupine
CAS: 32728-78-2
Ref. 3D-XH180148
| 1mg | 480.00 € | ||
| 2mg | 647.00 € | ||
| 5mg | 863.00 € | ||
| 10mg | 1,276.00 € | ||
| 25mg | 2,551.00 € |
Product Information
- D-erythro-Pentitol, 1,5-dideoxy-4-C-methyl-3-C-[[[(1S,7aR)-2,3,5,7a-tetrahydro-1-[[(2Z)-2-methyl-1-oxo-2-buten-1-yl]oxy]-1H-pyrrolizin-7-yl]methoxy]carbonyl]-
- D-erythro-Pentitol, 1,5-dideoxy-4-C-methyl-3-C-[[[(1S,7aR)-2,3,5,7a-tetrahydro-1-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-1H-pyrrolizin-7-yl]methoxy]carbonyl]-
- 1,5-Dideoxy-4-C-methyl-3-C-[[[(1S,7aR)-2,3,5,7a-tetrahydro-1-[[(2Z)-2-methyl-1-oxo-2-buten-1-yl]oxy]-1H-pyrrolizin-7-yl]methoxy]carbonyl]-D-erythro-pentitol
- 2-Butenoic acid, 2-methyl-, 7-[[2,3-dihydroxy-2-(1-hydroxyethyl)-3-methyl-1-oxobutoxy]methyl]-2,3,5,7a-tetrahydro-1H-pyrrolizin-1-yl ester, [1S-[1α(Z),7[R*(R*)],7aα]]-
Heliosupine is a tigloyl-acid n-oxide that belongs to the group of potent inducers of hepatic microsomal cytochrome P450. It has been shown to have genotoxic activity in vitro and in vivo, inducing DNA strand breaks and DNA crosslinks. The chemical structure of heliotridine is similar to retrorsine, which is also a potent inducer of hepatic microsomal cytochrome P450. Retrorsine has been shown to be toxic to rats and rabbits at high doses, but there is little evidence for toxicity at lower doses. Heliotridine has been shown to be toxic in mice and rats when given orally or intravenously, with the main effects being on the liver and kidney.
Chemical properties
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