Hemin

CAS: 16009-13-5

Ref. 3D-XH181795

Product Information

• Name: Hemin
• Synonyms: Hemin chloride Chloro(protoporphyrinato)iron(III) Hematin chloride, 1,3,5,8-Tetramethyl-2,4-divinylporphine-6,7-dipropionic acid ferrichloride, 21H,23H-Porphine-2,18-dipropanoic acid, 7,12-diethenyl-3,8,13,17-tetramethyl-, iron complex, Chloro[dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-)]iron, Chlorohemin, Chloroprotoferriheme, Chloroprotohemin, Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24]-, dihydrogen, (SP-5-13)-, Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N²¹,N²²,N²³,N²⁴]-, dihydrogen, (SP-5-13)-, Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN21,κN22,κN23,κN24]-, hydrogen (1:2), (SP-5-13)-, Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN²¹,κN²²,κN²³,κN²⁴]-, dihydrogen, (SP-5-13)-, Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN²¹,κN²²,κN²³,κN²⁴]-, hydrogen (1:2), (SP-5-13)-, Ferric hemin, Ferriheme, Ferriheme chloride, Ferriporphyrin chloride, Ferriprotoporphyrin, Ferriprotoporphyrin IX, Ferriprotoporphyrin IX chloride, Haemin, Hemin IX, Hemin chloride, Hemina, Hemine, Iron(III) protoporphyrin chloride, Iron, chloro[dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-)]-, Kjb 003, Panhematin, Protoferriheme, Protohemin, Protohemin IX, Protohemin chloride, Teichmann's crystals

Description

Hemin is an iron-containing porphyrin (Fe(III) complex of protoporphyrin IX) and is present in human blood. It plays an important role in immune response by facilitating hemoglobin release, increasing the production of reactive oxygen species (ROS) and promoting bacterial lysis. Hemin is also found in Porphyromonas gingivalis and hemophilus influenza bacteria and it may play a role in their virulence since it serves as an iron source for growing cultures. However, hemin has shown antibacterial properties when it binds to serum albumin and some modified porphyrins, and has been reported to trigger cell death in Porphyromonas gingivalis (an oral pathogen) by reducing the iron uptake. This might affect the levels of free hemin that actively affect the peroxidation of low-density lipoproteins (LDL). To prevent the peroxidation, hemopexin captures these globin-free hemin by binding to it and transporting it to the liver, where it is internalized and degraded.

• Brand: Biosynth

Chemical properties

• Molecular weight: 651.94 g/mol
• Formula: C₃₄H₃₂ClFeN₄O₄
• Purity: 98.0 To 100.0 Area-%
• Color/Form: Powder