HBTU

CAS: 94790-37-1

Ref. 3D-Z-1021

Product Information

• Name: HBTU
• Synonyms: N,N,N',N'-Tetramethyl-O-(1H-benzotriazol-1-yl)uronium hexafluorophosphateO-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate, 1-[Bis(dimethylamino)methylene]-1H-benzotriazolium hexafluorophosphate(1-) 3-oxide, 1H-Benzotriazolium, 1-[bis(dimethylamino)methylene]-, 3-oxide, hexafluorophosphate(1-) (1:1), 1H-Benzotriazolium, 1-[bis(dimethylamino)methylene]-, hexafluorophosphate(1-), 3-oxide, 2-(1H-Benzotriazole-1-Yl)-1,1,3,3-Tetramethyluronium Hexafluorophosphate, Hbtu, N-Hbtu, N-[(1H-benzotriazol-1-yloxy)(dimethylamino)methylidene]-N-methylmethanaminium hexafluorophosphate, O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium Hexafluorophosphate, O-Benzotriazole-N,N,N',N'-tetramethyl-uronium-hexafluoro-phosphate, O-Benzotriazole-N,N,N',N'-tetramethyl-uronium-hexafluorophosphate

Description

HBTU is a common reagent used for peptide coupling, which can be employed for amide and ester formation. It is stable, highly reactive, suitable for solid phase and in-solution synthesis. The major advantages of HBTU are high yields, fast reaction times, easy reaction conditions, racemisation control and ease of purification from the water-soluble by-products. HBTU contains both the carbodiimide function and the benzotriazole one, activating the carboxylic acid and forming HOBt in situ. Although HBTU was originally catalogued as uronium salt, X-ray diffraction showed evidence for it to be an aminium salt instead.

• Brand: Biosynth

Chemical properties

• Molecular weight: 379.24 g/mol
• Formula: C₁₁H₁₆F₆N₅OP
• Purity: Min. 99 Area-%