Product Information
- 7-Chloro-4-{4-[(4-Chlorophenyl)Sulfonyl]Piperazino}Quinoline
- Quinoline, 7-chloro-4-[4-[(4-chlorophenyl)sulfonyl]-1-piperazinyl]-
KM11060 is a peptide that has been shown to activate the ion channel TRPV1. It also inhibits the interaction of the receptor with its ligand. KM11060 is a potent inhibitor of TRPV1, and has been shown to inhibit the binding of ATP to TRPV1. KM11060 also inhibits the binding of ATP to TRPV2 and TRPA1 channels, but not TRPM8 channels.
TRPV1 channels are activated by several stimuli, including heat (>42°C), acidic pH (4.5), and capsaicin (the active ingredient in chili peppers). The activation of these channels leads to an influx of calcium ions into the cell, which can trigger pain sensations and inflammation.
Chemical properties
Technical inquiry about: 3D-ZFB54997 KM11060
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