t-BUTYLDIMETHYLSILYLTRIFLUOROMETHANESULFONATE

CAS: 69739-34-0

Ref. 3H-SIB1967.0

Product Information

• Name: t-BUTYLDIMETHYLSILYLTRIFLUOROMETHANESULFONATE
• Brand: Gelest
• Description: Trialkylsilyl Blocking AgentUsed as a protecting group for reactive hydrogens in alcohols, amines, thiols, and carboxylic acids. Organosilanes are hydrogen-like, can be introduced in high yield, and can be removed under selective conditions. They are stable over a wide range of reaction conditions and can be removed in the presence of other functional groups, including other protecting groups. The tolerance of silylated alcohols to chemical transformations summary is presented in Table 1 of the Silicon-Based Blocking Agents brochure.tert-Butyldimethylsilyltrifluoromethanesulfonate; TBS-OTf; t-ButyldimethylsilyltriflateMore reactive than SIB1935.0Converts acetates to TBS ethersUsed for the protection of alcohols, amines, thiols, lactams, and carboxylic acidsClean NMR characteristics of protecting groupFacile removal with flouride ion sourcesSummary of selective deprotection conditions is provided in Table 7 through Table 20 of the Silicon-Based Blocking Agents brochure

Chemical properties

• Molecular weight: 264.33
• Formula: C₇H₁₅F₃O₃SSi
• Color/Form: Straw Liquid