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A histamine H1 receptor antagonist

Ebastine

Ebastine

Ebastine (Kestine) (trade names Evastin, Kestine, Ebastel, Aleva) is a non-sedating H1 antihistamine.

Applications A nonsedating type histamine H1-receptor antagonist. Antihistaminic. References Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009), Inomata, N., et al.: J. Dermatol., 36, 224 (2009), Carvajal, A., et al.: Clin. Pharmacol. Ther., 85, 481 (2009), Yamashita, S., et al.: Mol. Pharm., 6, 48 (2009),

Ebastine is a H1 receptor antagonist that belongs to the group of antihistamines. Ebastine inhibits histamine release from mast cells and basophils and may also have some anticancer activity. It has been shown to be effective in clinical trials, used to treat rhinitis and allergic symptoms such as itching and watery eyes. Ebastine is also non-sedating is not metabolized by cytochrome P450 enzymes but may affect their activity due to its binding affinity for proteins such as albumin and α1-acid glycoprotein.

EBASTINE CRS