CAS 90729-43-4
:Ebastine
Description:
Ebastine is a second-generation antihistamine primarily used to alleviate allergic symptoms such as rhinitis and urticaria. It functions as a selective antagonist of the H1 histamine receptor, which helps reduce the effects of histamine in the body, thereby mitigating allergic reactions. Ebastine is characterized by its relatively low sedative effects compared to first-generation antihistamines, making it suitable for long-term use without significant drowsiness. The substance is typically administered orally and is known for its rapid absorption and metabolism, with a half-life that allows for once-daily dosing. Chemically, ebastine is a piperidine derivative, and its structure includes a phenyl group, contributing to its pharmacological activity. It is generally well-tolerated, with a side effect profile that may include headache, fatigue, and dry mouth, although these are less common. Ebastine is also notable for its ability to cross the blood-brain barrier to a lesser extent than older antihistamines, which is a key factor in its reduced sedative properties.
Formula:C32H39NO2
InChI:InChI=1/C32H39NO2/c1-32(2,3)28-18-16-25(17-19-28)30(34)15-10-22-33-23-20-29(21-24-33)35-31(26-11-6-4-7-12-26)27-13-8-5-9-14-27/h4-9,11-14,16-19,29,31H,10,15,20-24H2,1-3H3
InChI key:InChIKey=MJJALKDDGIKVBE-UHFFFAOYSA-N
SMILES:C(OC1CCN(CCCC(=O)C2=CC=C(C(C)(C)C)C=C2)CC1)(C3=CC=CC=C3)C4=CC=CC=C4
Synonyms:- 1-(4-(1,1-Dimethylethyl)phenyl)-4-(4-(diphenylmethoxy)-1-piperidinyl)-1-butanone
- 1-(4-Tert-Butylphenyl)-4-[4-(Diphenylmethoxy)Piperidin-1-Yl]Butan-1-One
- 1-Butanone, 1-(4-(1,1-dimethylethyl)phenyl)-4-(4-(diphenylmethoxy)-1-piperidinyl)-
- 4'-tert-Butyl-4-(4-(diphenylmethoxy)piperidino)butyrophenone
- 4-Diphenylmethoxy-1-(3-(4-tert-butylbenzoyl)propyl)piperidine
- Bastel
- Ebastel
- Ebastin
- Ebastina
- Ebastina [Spanish]
- Ebastine [USAN:INN]
- Ebastinum
- Ebastinum [Latin]
- Erostin
- Kestine
- Las W-090
- Rp 64305
- Unii-Tqd7Q784P1
- Ebastine
- EBASTINE, IMPURITY C4-(DIPHENYLMETHOXY)PIPERIDINE EP STANDARD
- 4-(4-benzhydryloxy-1-piperidyl)-1-(4-tert-butylphenyl)butan-1-one
- Ebasine
- EBASTINE, IMPURITY D1-[4-(1,1-DIMETHYLETHYL)PHENYL]-4-(4-HYDROXYPIPERIDIN-1-YL)BUTAN-1-ONE EP STANDARD
- 1-butanone,1-(4-(1,1-dimethylethyl)phenyl)-4-(4-(diphenylmethoxy)-1-piperidiny
- Estivan
- EVASTEL
- EBASTINE, MM STANDARD
- EBASTINE, REFERENCE SPECTRUM EP STANDARD
- See more synonyms
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Ebastine
CAS:Formula:C32H39NO2Purity:>98.0%(HPLC)(T)Color and Shape:White to Almost white powder to crystalMolecular weight:469.671-[4-(1,1-Dimethylethyl)phenyl]-4-[4-(diphenylmethoxy)-1-piperidinyl]-1-butanone
CAS:Formula:C32H39NO2Purity:98%Color and Shape:SolidMolecular weight:469.6576Ebastine (Standard)
CAS:Ebastine (Standard) is the standard substance of Ebastine, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Ebastine (Kestine) (trade names Evastin, Kestine, Ebastel, Aleva) is a non-sedating H1 antihistamine. It does not penetrate the blood-brain barrier and thus allows an effective block of the H1 receptor in peripheral tissue without a central side effect, i. e not causing sedation or drowsiness.Formula:C32H39NO2Molecular weight:469.6576Ebastine
CAS:Applications A nonsedating type histamine H1-receptor antagonist. Antihistaminic.
References Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009), Inomata, N., et al.: J. Dermatol., 36, 224 (2009), Carvajal, A., et al.: Clin. Pharmacol. Ther., 85, 481 (2009), Yamashita, S., et al.: Mol. Pharm., 6, 48 (2009),Formula:C32H39NO2Color and Shape:NeatMolecular weight:469.66Ebastine
CAS:Ebastine (Kestine) (trade names Evastin, Kestine, Ebastel, Aleva) is a non-sedating H1 antihistamine.Formula:C32H39NO2Purity:99.65% - 99.99%Color and Shape:White To Off-White PowderMolecular weight:469.6576Ebastine
CAS:4-(4-(Benzhydryloxy)piperidin-1-yl)-1-(4-(tert-butyl)phenyl)butan-1-oneFormula:C32H39NO2Purity:98%Molecular weight:469.66Ebastine
CAS:Ebastine is a H1 receptor antagonist that belongs to the group of antihistamines. Ebastine inhibits histamine release from mast cells and basophils and may also have some anticancer activity. It has been shown to be effective in clinical trials, used to treat rhinitis and allergic symptoms such as itching and watery eyes. Ebastine is also non-sedating is not metabolized by cytochrome P450 enzymes but may affect their activity due to its binding affinity for proteins such as albumin and α1-acid glycoprotein.Formula:C32H39NO2Purity:Min. 95%Color and Shape:White PowderMolecular weight:469.66 g/molEbastine - Bio-X ™
CAS:Ebastine is a H1 receptor antagonist that belongs to the group of antihistamines. Ebastine inhibits histamine release from mast cells and basophils and may also have some anticancer activity. It has been shown to be effective in clinical trials, used to treat rhinitis and allergic symptoms such as itching and watery eyes. Ebastine is also non-sedating is not metabolized by cytochrome P450 enzymes but may affect their activity due to its binding affinity for proteins such as albumin and α1-acid glycoprotein.Formula:C32H39NO2Purity:(%) Min. 95%Color and Shape:PowderMolecular weight:469.66 g/mol
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