86-MM0681.06-0025 - methyl-6-3-1-adamantyl-4-methoxyphenyl-2-naphthoate-adapalene-methyl-ester

Carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides etc, nesoi

Methyl 6-(3-(adamantan-1-yl)-4-methoxyphenyl)-2-naphthoate

<p>Impurity Adapalene USP Related Compound B<br>Applications Adapalene intermediate, an ester of Adapalene. Adapalene USP Related Compound B.<br>References Charpentier, B., et al.: J. Med. Chem., 38, 4993 (1995),<br></p>

<p>Adapalene is an organic solvent that can be used as a Grignard reagent. It is also a chromatographic solvent and has a high boiling point. Adapalene is the sodium salt of adapalene, which dissolves in water. The pharmacopeial grade of adapalene is in the form of a white or almost white crystalline powder with a molecular weight of 388.5 and a melting point of 130-132°C. Adapalene has been shown to inhibit the activity of the enzyme tyrosinase, which converts tyrosine to L-DOPA, leading to decreased production of melanin. This process can be catalyzed by magnesium ions or by ligands such as phenols and amines.</p>