86-MM3428.00-0250 - fludarabine-phosphate | 75607-67-9

Fludarabine phosphate

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Fludarabine Phosphate

Fludarabine Phosphate

Fludarabine Phosphate (NSC 312887 Phosphate) is a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine with antineoplastic activity.

<p>Applications 4-Desfluoro-4-(1,2,4-triazol-1-yl)phenyl Fluconazole is an impurity in the synthesis of Fluconazole (F421000), used as an antifungal.<br>References Richard, K. et al.: Antimicrob. Ag. Chemother., 27, 832 (1985);<br></p>

<p>Fludarabine phosphate is an antileukemic drug that inhibits DNA polymerase α and β, as well as other enzymes in the nucleotide synthesis pathway. It is used to treat patients with chronic myelogenous leukemia (CML) who have developed resistance to other treatments. Fludarabine phosphate has been shown to induce a cytotoxic effect against tumor cells by binding to ATP-binding cassette transporter proteins on the cell membrane and inhibiting intracellular targets such as DNA, RNA, and protein synthesis. Fludarabine phosphate has also been shown to inhibit the growth of tumor cells through synergistic interactions with other anticancer drugs such as hydroxyurea or busulfan, which may be due to its ability to inhibit enzyme activities such as erythrocyte alkaline phosphatase.</p>

FLUDARABINE PHOSPHATE CRS