AC-46989 - sodium-thiomethoxide-90-technical | 5188-07-8

Applications Strong nucleophile used for the synthesis of methyl aryl sulfides from halo-arenes. Alkanethiolates are efficient reagents for SN2 dealkylation of esters and aryl ethers.
E0
References Le Brazidec, J., et al.: J. Med. Chem., 47, 3865 (2004), Grem, J., et al.: J. Clin. Oncol., 23, 1885 (2005), Levason, W., et al.: Dalton Trans, 439 (2007),

Stability Readily Oxidized
Applications A volatile aroma compound. We will provide a detailed procedure for the preparation of the thiol from the thiolacetate with spectral data upon request.
References Majcher, M., et al.: J. Agric. Food Chem., 55, 5754 (2007), Akiyama, M., et al.: Food Sci. Technol. Res., 15, 233 (2009), Breme, K., et al.: J. Agric. Food Chem., 57, 8572 (2009),

Applications Sodium Methanethiolate-13C, is the labeled analogue of Sodium Methanethiolate (S644805), used as a nucleophile in organic synthesis. Sodium methanethiolate is also being used as a reagent to synthesize thiol-based suberoylanilide hydroxamic acid (SAHA) analogues, compounds that act as potent histone deacetylase inhibitors.
References Bergman, A. & Wachtmeister, Chemosphere, 7, 949 (1978); Suzuki, T.,et al.: Bioorg. Med. Chem. Lett., 14, 3313 (2004)

Methanethiol is a compound that occurs naturally in the environment. It is used as a fungicide, insecticide and herbicide. Methanethiol inhibits the growth of microorganisms by binding to metal ions on the surface of cells. This prevents DNA replication and protein synthesis, leading to cell death. Methanethiol also has anti-inflammatory properties which may be due to its ability to inhibit adenosine A1 receptor activity in humans.