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Aristolochic acid A

Aristolochic acid A

CAS 313-67-7

Ref. BP-BP0192

20mg
100mg
201.00 €
379.00 €
Estimated delivery time: ~13 days

Product Information

Name:
Aristolochic acid A
Long term storage:
Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Notes:

Aristolochic acid can induce proximal tubule apoptosis and epithelial to mesenchymal transformation.[4]
Aristolochic acid induces tumors in rats and mice, activates mutations at codon 61 of the c-Ha- ras gene in thin-tissue sections of tumors. [5]
Aristolochic acid, a potent human carcinogen produced by Aristolochia plants, is associated with urothelial carcinoma of the upper urinary tract (UUC), exposure to aristolochic acid contributes significantly to the incidence of UUC in Taiwan and endemic (Balkan) nephropathy .[1]
DNA damage by aristolochic acid (AA) is not only responsible for the tumour development but also for the destructive fibrotic process in the kidney; AA is a powerful nephrotoxic and carcinogenic substance with an extremely short latency period, not only in animals but also in humans, therefore, all products containing botanicals known to or suspected of containing AA should be banned from the market world wide.[2,3]
Inquire for bulk scale.
The product could be supplied from milligrams to grams, up to kilograms
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
analysis-method: HPLC-DAD or/and HPLC-ELSD
botanical-source: Alkaloid from a wide range of Aristolochia spp. Also found in the Chinese drug Fang-chi, Asarum canadense var. reflexum, Bragantia wallichii (preferred genus name Thottea), and in the butterflies Pachlioptera aristolochiae and Battus archidamas
identification-method: Mass, NMR
type-of-compound: Miscellaneous


Chemical properties

Molecular weight:
341.275
Formula:
C17H11NO7
Purity:
98%
Color/Form:
Yellow powder

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