Product Information
- (3Beta,5Beta,8Xi,9Xi)-3,14-Dihydroxybufa-20,22-Dienolide
- (3β,5β)-3,14-Dihydroxybufa-20,22-dienolide
- 3,14-Dihydroxybufa-20,22-Dienolide
- 5β-Bufa-20,22-dienolide, 3β,14-dihydroxy-
- B 0261
- Bufa-20,22-dienolide, 3,14-dihydroxy-, (3β,5β)-
- NSC 89595
Bufalin a major digoxin-like immunoreactive component of the Chinese medicine Chan Su; has been shown to exert a potential for anticancer activity against various human cancer cell lines in vitro. Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators steroid receptor coactivator (SRC)-3 and SRC-1, it also as a potentially broad-spectrum small-molecule inhibitor for cancer. Bufalin can partly reverse the MDR of K562/VCR cells, with a possible mechanism of down-regulating MRP1 expression and activating apoptosis pathway by altering Bcl-xL/Bax ratio.
Chemical properties
Technical inquiry about: BP-BP0288 Bufalin
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