Calycosin

CAS: 20575-57-9

Ref. BP-BP0305

Product Information

• Name: Calycosin
• Synonyms: 3′,7-Dihydroxy-4′-methoxyisoflavone, 3-Hydroxyformononetin, Cyclosin, 3′-Hydroxyformononetin, 4H-1-benzopyran-4-one, 7-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-, 7,3′-Dihydroxy-4′-methoxyisoflavone, 7-Hydroxy-3-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one, 7-Hydroxy-3-(3-hydroxy-4-methoxyphenyl)benzopyran-4-one, Cyclosin (isoflavone), Isoflavone, 3′,7-dihydroxy-4′-methoxy-

Description

Calycosin, a major isoflavonoid isolated from Radix Astragal, induces angiogenesis in human umbilical vein endothelial cell cultures (HUVEC) in vitro and zebrafish embryos in vivo via the up-regulation of vascular endothelial growth factor (VEGF), VEGFR1 and VEGFR2 mRNA expression;it acts similar to other selective estrogen receptor modulators (SERMs) to promote angiogenesis via activation of MAPK with the involvement of ERK1/2 and ER. , such as raloxifene and tamoxifen, by displaying selective potency and affinity to estrogen receptors ERa and ERb.

• Brand: Biopurify

Chemical properties

• Molecular weight: 284.267
• Formula: C₁₆H₁₂O₅
• Purity: 95%~99%
• Color/Form: Yellow powder
• InChI: InChI=1S/C16H12O5/c1-20-14-5-2-9(6-13(14)18)12-8-21-15-7-10(17)3-4-11(15)16(12)19/h2-8,17-18H,1H3
• InChI key: InChIKey=ZZAJQOPSWWVMBI-UHFFFAOYSA-N
• SMILES: COc1ccc(-c2coc3cc(O)ccc3c2=O)cc1O