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Catalpol

Catalpol

CAS 2415-24-9

Ref. BP-BP0321

20mg
100mg
1000mg
156.00 €
205.00 €
348.00 €
Estimated delivery time: ~13 days

Product Information

Name:
Catalpol
Synonyms:
  • Catalpinoside
Long term storage:
Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Notes:

Catalpol can increase presynaptic proteins and up-regulate relative signaling molecules in the hippocampus of the aged rats, it seems to indicate that catalpol might ameliorate age-related neuroplasticity loss by “normalizing” presynaptic proteins and their relative signaling pathways in the aged rats.[4]
Catalpol exerts the most significant cytoprotective effect on astrocytes by suppressing the production of free radicals and elevating antioxidant capacity.[3]
Catalpol has the neuroprotective effects of in lipopolysaccharide (LPS)-induced inflammatory models, it can prevent mesencephalic neuron death and ameliorate cognitive ability animals; catalpol can exert inhibitory effects on the inflammatory reaction in astrocytes and that inactivation of NF-κB could be the major determinant for its anti-inflammatory mechanism, therefore, it may potentially be a highly effective therapeutic agent in treating neurodegenerative diseases associated with inflammation.[2]
Catalpol, an iridoid glucoside, has been reported to inhibit apoptosis of neuron and endothelial cells; the pretreatment of H9c2 cells with catalpol can be against H 2 O 2 -induced apoptosis, and the protective effect of catalpol involves the mitochondrial-dependent caspase pathway and is associated with increased Bcl-2 and decreased Bax expression.[1]
Inquire for bulk scale.
The product could be supplied from milligrams to grams, up to kilograms
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
[1] Hu L A, Sun Y K, Zhang H S, et al. Bioscience Reports, 2016,36(3).
analysis-method: HPLC-DAD or/and HPLC-ELSD
botanical-source: Plantago lanceolata, Buddleia globosa, Buddleia variabilis and Lagotis brevituba
identification-method: Mass, NMR
type-of-compound: Iridoids


Chemical properties

Molecular weight:
362.331
Formula:
C15H22O10
Purity:
98%
Color/Form:
Powder

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