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CAS: 553-21-9

Ref. BP-BP0401

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Estimated delivery in United States, on Monday 15 Jun 2020

Product Information

Long term storage:
Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.

Costunolide can reduce the viability and arrest cell cycling at mitosis in hepatoma cells, also enhance the killing effect of radiotherapy against human HCC cells.[5]
Costunolide has antipyretic and anti-inflammatory activities, intraplantar injection of costunolide also reduced the paw oedema, myeloperoxidase. [3]
Costunolide induces the ROS-mediated mitochondrial permeability transition and resultant cytochrome c release,which is one mechanism of the anticancer effect of costunolide. [2]
Costunolide(20mg/kg bw) possesses normo-glycemic and hypolipidemic activity and hence it could be used as a drug for treating diabetes. [4]
Costunolide, a sesquiterpene lactone isolated from the root of Saussurea lappa Clarke, has a variety of biological activities, including anti-carcinogenic and anti-fungal activities,
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Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
analysis-method: HPLC-DAD or/and HPLC-ELSD
botanical-source: costus root (Saussurea lappa), Artemisia balchanorum, Talauma ovata, Talauma mexicana, Liriodendron tulipifera, Frullania tamarischii, Frullania nisquallensis, Michelia spp., Magnolia grandiflora, Magnolia sieboldii, Gochnatia foliosa, Chrysa
identification-method: Mass, NMR
it inhibits IL-1beta gene expression by blocking the activation of MAPKs and DNA binding of AP-1 in LPS-stimulated RAW 264.7 cells. [1]
type-of-compound: Sesquiterpenoids

Chemical properties

Molecular weight:

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