Product correctly added to cart.

discount label

Cucurbitacin B

CAS: 6199-67-3

Ref. BP-BP0414

{user_price} € Add to cart
Estimated delivery in United States, on Monday 15 Jun 2020

Product Information

Cucurbitacin B
  • Amarin
Long term storage:
Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.

Combination of cucurbitacin B at a relatively low concentration with either of the chemotherapeutic agents, docetaxel (DOC) or gemcitabine (GEM) , shows prominent antiproliferative activity against breast cancer cells without increased toxicity, this promising combination should be examined in therapeutic trials of breast cancer.[4]
Cucurbitacin B (cucB) is a triterpenoid constituent of Cucurbitaceae vegetables and a promising phytochemical for cancer prevention, cucB induces G(2) arrest and apoptosis through a STAT3-independent but ROS-dependent mechanism in SW480 cells.[1]
Cucurbitacin B a selective inhibitor of JAK2/STAT3 signaling, could promote dendritic cells (DCs) differentiation and improve antitumor immunity, also significantly reduce the frequency of imCs in patients with lung cancers and enhance the effect of p53-specific CTL on tumor 16HBE/BPDE cells.[6]
Cucurbitacin B has anti-cutaneous squamous cell carcinoma (CSCC) activity by inhibiting growth, arresting the cell cycle, and synergistically potentiate the anti-proliferative effect of cisplatin in CSCC.[5]
Cucurbitacin B has antiproliferative effect, can induce apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells, may be an effective, new approach for the treatment of ER-, Her2/neu amplified, and p53 mutant breast cancers.[2,3]
Inquire for bulk scale.
The product could be supplied from milligrams to grams, up to kilograms
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
analysis-method: HPLC-DAD or/and HPLC-ELSD
botanical-source: Bitter principle of fruits of Cucurbitaceae, also present in some other plants, e.g. Anagallis arvensis, Luffa acutangula, Luffa graveolens, Luffa echinata, Echinocystis fabacea, Iberis spp., Begonia tuberhybris-alba, Begonia heracleifolia, Bryonia alba,
identification-method: Mass, NMR
type-of-compound: Triterpenoids

Chemical properties

Molecular weight:
White powder

Technical inquiry

Please use instead the cart to request a quotation or an order

If you want to request a quotation or place an order, please instead add the desired products to your cart and then request a quotation or order from the cart. It is faster, cheaper, and you will be able to benefit from the available discounts and other advantages.

Please make sure to include the country code in the phone number. Check Wikipedia to find the country code.

Thank you!

Use of cookies

We use our own and third-party cookies to improve our services and show you advertisements related to your preferences by analyzing your browsing habits. You can get more information in our Cookies Policy .