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Fangchinoline (Fan) has anti-tumorigenic activity in vivo, including reduction of tumor volume and pro-apoptotic and anti-proliferative effects in a PC3 nude mouse xenograft, it inhibits human prostate cancer cell lines (PC3) cell proliferation in a dose- and time-dependent manner, the anti-proliferative effect is associated with an increase in the G1/S phase of PC3 cells, suggests that Fan is an effective anti-proliferative agent that modulates cell growth regulators in prostate cancer cells.
Fangchinoline and tetrandrine are the major alkaloids from Stephania tetrandrae S. they shows anti-inflammatory effects on mouse ear edema induced by croton oil, the biochemical mechanisms of fangchinoline and tetrandrine on anti-inflammation are significantly different even though they are similar in chemical structure.
Fangchinoline and tetrandrine have vasodilating and hypotensive effects on the rat aorta and the stroke-prone spontaneously hypertensive rat.
Fangchinoline can enhance the cytotoxicity of multidrug resistance-related drugs via modulation of P-glycoprotein.
Fangchinoline can inhibit human immunodeficiency virus type 1 replication by interfering with gp160 proteolytic processing.
Fangchinoline has effective antioxidant and radical scavenging activity, also has protective effects on hydrogen peroxide-induced oxidative neuronal cell damage in cultured rat cerebellar granule cells.
Fangchinoline is a highly specific agent inducing autophagic cell death via p53/sestrin2/AMPK signalling in hepatocellular carcinoma cells with a novel mechanism, which elucidates the potential of fangchinoline to potentiate programmed cell death in cancer cells.
Fangchinoline is a nonspecific Ca(2+) channel blocker, it reduces both FBS- and PDGF-BB-induced RASMCs proliferation by perturbing cell cycle progression; this antiproliferative effect of FAN is dependent on the MAP kinase pathway, but cannot be limited to its Ca(2+) modulation.
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The product could be supplied from milligrams to grams, up to kilograms
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
analysis-method: HPLC-DAD or/and HPLC-ELSD
botanical-source: Alkaloid from Root of Cyclea peltata, Triclisia subcordata and Stephania hernandifolia, the tubers of Stephania tetrandra, and from the bark of Daphnandra sp. Dt-7 (Menispermaceae, Atherospermacaceae).
identification-method: Mass, NMR
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